In electron microscopes, Ruth Bishop saw spherical RNA virus {rotavirus}| in small intestines of children with severe diarrhea [1973]. RNA has 11 segments. Rotavirus looks like wheels, has double-stranded RNA, and has three protein layers. VP7 is outer layer and has VP4 spikes for attachment. Splitting VP4 in host makes VP5 and VP8 for host entry. VP6 is middle layer and is for gene transcription. VP2 is inner layer. VP1 and VP3 enzymes copy virus genes. Rotavirus makes NSP4 toxin.
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Date Modified: 2022.0224