5-Chemistry-Biochemistry-Drug-Mechanics-Lipophilicity

lipophilicity

Compounds can have good solubility in lipids {lipophilicity}.

Fujita-Hansch pi value

Values {Fujita-Hansch pi value} can relate to lipophilicity.

log P

Octanol/water partition coefficient logarithms {log P} can measure lipophilicity.

molecular lipophilicity potential

Hydrophobicity measures {molecular lipophilicity potential} (MLP) can calculate lipophilicity surface.

octanol-buffer partition

Lipophilic compounds can diffuse across lipid membrane {octanol-buffer partition coefficient theory}.

P-glycoprotein

On brain-capillary endothelial-cell insides, proteins {P-glycoprotein} can prevent high-lipophilicity drugs from crossing BBB.

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Date Modified: 2022.0225