4-Zoology-Organ-Nerve-Neuron-Physiology-Regulation

down-regulation

At receptor, catecholamine agonist causes desensitization {tolerance, regulation}, because agonist receptors have reduced affinity and subsequently decrease in number {down-regulation}. Down-regulation persists for days after transmitter concentrations have returned to normal {temporal amplification, down-regulation}.

up-regulation

Denervation, catecholamine depletion, or catecholamine antagonist treatment causes suprasensitivity {up-regulation}, because receptor number increases. Up-regulation persists for days after transmitter concentrations have returned to normal {temporal amplification, up-regulation}.

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4-Zoology-Organ-Nerve-Neuron-Physiology

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Date Modified: 2022.0225