Calcium ion entry can activate proteins {cAMP-response element} {cyclic-AMP response element} (CRE) (CRE-1) {cAMP-response element binding protein-1} (CREB-1) {CREB protein} that bind to regulatory regions and activate cyclic-AMP and cyclic-AMP-receptor genes. CREB also activates immediate early genes, such as ubiquitin hydrolase and C/EBP transcription factor, to initiate synaptic growth. CREB regulates endorphin production.
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Date Modified: 2022.0224