Nociceptors {cannabinoid receptor} (CB1) can have cannabis receptors. Anandamide, 2-arachidonoyl glycerol (2-AG), and marijuana delta-9-tetrahydrocannabinol (THC) bind in hypothalamus, basal ganglia, amygdala, brainstem, hippocampus, cerebellum, and neocortex. Hypothalamus affects appetite, sex, and hormones. Basal ganglia affect motor acts and planning. Amygdala affects emotion, anxiety, and fear. Brainstem affects pain and reflexes. Hippocampus affects memory and learning. Cerebellum affects motor acts. Neocortex affects sense qualities and cognition.
2-AG flows from receptor cell back to transmitting cell to decrease GABA {depolarization-induced suppression of inhibition} (DSI) [Earleywine, 2002] [Grinspoon and Bakalar, 1993].
immune
CB2 receptor is only in immune system.
Biological Sciences>Zoology>Organ>Nerve>Neural Chemical>Receptor
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Date Modified: 2022.0224