biological clock

In mammals, Mop3 gene product is main component of 24-hour biological clocks {biological clock}|, in hypothalamus, eye, testis, ovary, liver, heart, lung, and kidney, which work by positive and negative feedback among proteins. Mammals can rest themselves according to environment. Mutant Mop3 requires homozygosity. Clock-gene product acts as a pacemaker in hypothalamus suprachiasmatic nucleus (SCN), which synchronizes other organ clocks. CLOCK, PER, and MOP3 proteins have PAS domains. Circadian rhythm affects albumin D-element-binding protein {mDbp}, which does not regulate circadian rhythm.

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