Yeast, worm, and fruitfly SIR2 gene makes sir2 protein. Humans SIRT1 gene makes sirt1 protein. Sirtuins {silent information regulators} {sirtuin} slow aging, by mediating stress responses and deacetylating histones to make DNA coil tighter and prevent extra DNA production. Low calorie intake, high salt, high heat, and low nitrogen intake can increase PNC1-gene production, remove nicotinamide, and increase sirtuins. Low calorie intake causes mitochondria to respire instead of ferment, making low NADH and high NAD and increasing sirtuins. Red-wine and knotweed have resveratrol, which increases sirtuins.
Biological Sciences>Zoology>Development>Aging>Cell
4-Zoology-Development-Aging-Cell
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Date Modified: 2022.0224