Methicillin-resistant Staphylococcus aureus (MRSA) makes enzyme that splits antibiotic {antibiotic resistance}. Vancomycin-resistant Staphylococcus aureus (VRSA) has five-gene cassette that alters cell-wall receptor. Bacteria can make cell-membrane systems that pump out antibiotics.
As part of SOS response, bacterial cells can attach RecA protein to single-stranded DNA, which splits LexA regulatory protein, which derepresses genes that cause DNA mutations, which alter drug targets. Binding compound to LexA first, to prevent splitting by RecA, can prevent mutation resistance.
Biological Sciences>Medicine>Drug>Kinds>Antibiotic
4-Medicine-Drug-Kinds-Antibiotic
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Date Modified: 2022.0224