Dyskinesia {chorea}| can have too much dopamine in brain movement-control centers and cause quick muscle contractions. People can twist or writhe in athetosis. Huntington's chorea is hereditary. Syndenham's chorea is from rheumatic fever. Drugs, hormonal disorders, and blood vessel problems can cause chorea.
Dominantly inherited disorders {Huntington's chorea} {Huntington chorea} {Huntington's disease} can result from expanded glutamine repeats in HD proteins.
symptoms
At first, patients fidget, have spontaneous movements, and appear clumsy. Later, jerking and writhing affect face, tongue, and arms.
biology
A chromosome-4-tip autosomal dominant gene can cause Huntington's chorea. Cytosine-adenine-guanine nucleotides {CAG repeat, Huntington's} repeat in middle too many times, making too many glutamines. Proteins clump together {polyglutamine disease, Huntington's} to make protofibrils and later plaques. Cerebrum shrinks, ventricles enlarge, and midbrain caudate nucleus and putamen have damage. Cytosine-anything-guanine regions {CxG region, Huntington's} make DNA hairpins, so copies are longer.
After streptococcus infection, children 5 to 15 years old can have twisting chorea {St. Vitus' dance}| {Syndenham chorea}.
4-Medicine-Disease-Kinds-Organ-Nerve-Muscle
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Date Modified: 2022.0225