Addison's disease, anti-phospholipid syndrome, type 1 insulin-dependent diabetes, rheumatoid arthritis, celiac disease, multiple sclerosis, and systemic lupus erythematosus have antibodies {autoantibody} to body tissues {autoimmune disease}|. T-cell antibodies start to attack cells up to 10 years before symptoms appear. B cells can make autoantibodies used in diagnosis.
Enzymes can break down cells {autolysis}.
Adenosine-deaminase (ADA) gene damage prevents making immune system cells {immunodeficiency}|. HIV virus destroys helper T cells and causes acquired immunodeficiency syndrome (AIDS).
Bacteria chemicals can dilate arteries, causing reddening and high temperature {inflammation}|. Inflammation allows white blood cells to leave blood and attack foreign tissues. Leukocytes pass through artery walls, locate bacteria chemically, and phagocytize bacteria. Inflamed tissues increase white-cell production. Myeloperoxidase (MPO) indicates inflammation amount. Blood-vessel inflammation starts and assists atherosclerosis. LDL can cause vessel inflammation.
Oxygen activates protein complexes {inflammasome} {Nalp3 inflammasome} that cause inflammation.
Enzymes that lyse dead-cell molecules can not work well and leave DNA pieces, to which antibodies develop, causing inflammation {lupus}| {systemic lupus erythremosis}. Lupus patients have low DNAase-1. LymphoStat-B monoclonal antibody inhibits B-cell stimulators {B-lymphocyte stimulator} (BLyS). Lupus affects 200,000 to 500,000 people each year in USA.
Diseases can prevent calcium ions from passing into T cells {severe combined immunodeficiency syndrome} (SCIDS).
Autoimmune diseases {Sjögren's syndrome} {Sjögren syndrome} can attack secretory-gland tissues, causing dry mouth and eyes, plus teeth and eye problems. Sjögren's syndrome is in about 1% of people and affects women most. It can lead to lymphoma.
Cells can react to chemical substances {allergy}|. Chemical substances release muscle-constricting and blood-vessel-relaxing chemicals {histamine, allergy}. Antihistamines can block histamine chemical reactions and treat allergies. Food allergans include gluten and soybean p34 protein. Peanuts, tree nuts, milk, eggs, shellfish, and fish have allergans. Gluten causes celiac sprue. Allergies can involve tens of genes.
Histamines can cause hives, eye burning, shock, breath shortness, hard breathing, and edema {allergic reaction}|.
Histamines can cause nausea, weakness, low temperature, and convulsions {anaphylaxis}|.
Lungs can have allergic reactions {atopy} {asthma}|. Eczema, hay fever, anaphylaxis to bee sting or peanuts, and other allergies involve immunoglobulin and histamine.
causes
Dust-mite dung, pollen, feathers, molds, foods, metal vapor, plastics, wood, cigarette smoke, paint, sprays, aspirin, heart drugs, and exhaust gases can cause asthma. Immunization can activate Th1 cells. Mycobacteria can activate Th2 cells. Perhaps, virus exposure, isocyanate, trimellitic anhydride, and phthalic anhydride cause asthma.
biology
Immunoglobulin-E release signals mast cells, which release histamines. Asthma can cause smooth muscle to contract uncontrollably.
Pollen allergies {hay fever}| affect eye, throat, and lung mucous membranes.
Allergic reactions {hives}| can cause itching skin welts.
4-Medicine-Disease-Kinds-Organ
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Date Modified: 2022.0225