Metal-dependent endopeptidases {metalloproteinase} can break down interstitial type I, II, or III collagen, basement-membrane type IV collagen, or type V collagen. Metalloproteinases {matrilysin} {PUMP-1 gene} can split extracellular matrix. Metalloproteinases {gelatinase A} {gelatinase B} split basement membrane. MMP-1 and MMP-13 split interstitial collagen. Metalloproteinase {stromelysin-3} (MMP-3) splits extracellular matrix.
Plasminogen activators and other serine proteinases activate metalloproteinases. Cells have tissue metalloproteinase inhibitors {TIMP gene}, such as TIMP-1, TIMP-2, TIMP-3, and TIMP-4.
Biological Sciences>Genetics>Gene
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Date Modified: 2022.0224