Gene {archipelago gene} (ago gene) (AGO gene) products {ago protein} can regulate cell cycle, cell-differentiation Notch signaling pathway, and Alzheimer's-disease beta-amyloid precursor protein (APP) processing pathway. Ago protein contains F-box domain and seven WD40 repeat motifs. F-boxes and WD40 repeats are typically in ubiquitin-ligase complexes of ubiquitin/proteasome proteolytic pathway.
F-box
F-box domain interacts with proteins {Skp1 protein} of protein complexes {SCF complex}. Organisms have many F-box proteins, with more than 100 in Caenorhabditis elegans roundworm, for example.
WD40
WD40 repeats interact with cyclin E and cyclin F. WD40 repeats have repeating units of 40 amino acids, with tryptophan, with symbol W, and aspartic acid, with symbol D, at defined positions.
LRR repeats
Leucine-rich repeats {LRR repeat} interact with cyclin E.
cyclin E
Ago protein recognizes cyclin E and catalyzes covalent ubiquitin-to-cyclin-E attachment. Ago protein decreases cell proliferation by this mechanism.
Biological Sciences>Genetics>Gene>Cell Cycle
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Date Modified: 2022.0224