4-Biology-History

biology in history

Biology includes anatomy, botany, cell biology, genetics, nutrition, physiology, and zoology.

4-Biology-History-Anatomy

Alcmaeon

He lived -535 to -440 and dissected animals. Body has opposing powers, hot/cold and wet/dry, which balance in health. Galen later used this idea.

Hippocrates medicine

He lived -460 to -377. The "father of medicine" wrote case histories, disease observations, and Hippocratic oath. He described trephining skull holes. Disease results from humor essence imbalance.

Herophilus

He lived -335 to -280, dissected human body, and compared to other animal bodies. He described brain, brain ventricles, heart, heart valves, nervous system, sense and motor nerves, cornea, sclera, choroid, retina, and lens. He founded medical school at Alexandria.

Erasistratus

He lived -304 to -250, dissected animals and humans, and described brain, brain ventricles, heart, heart valves, nervous system, sense and motor nerves, cornea, sclera, choroid, retina, and lens.

Galen medicine

He lived 131 to 201 and probably developed the fourth syllogism figure. He diagnosed disease by pulse, dissected animals, and observed living and dead nerves, blood, and organs. Blood flows back and forth through body. Following Erasistratus [-280], body has three spirit types {pneuma, Galen}: natural spirit from liver, vital spirit from left heart ventricle, and animal spirit from brain. The four temperaments {temperaments, Galen} are choleric, melancholic, phlegmatic, and sanguine.

Vesalius A

He lived 1514 to 1564 and studied animal and human anatomy.

Janssen Z

He lived 1580 to 1638. With his father, he helped invent compound microscopes and used them.

Malpighi M

He lived 1628 to 1694, observed plant and animal tissues under microscope, and started embryology and histology.

Leeuwenhoek A

He lived 1632 to 1723 and observed bacteria [1674], yeast, protozoa, sperm, and capillary blood corpuscles under microscope.

La Mettrie J

He lived 1709 to 1751, was materialist, and was Boerhaave's student. Cells have intrinsic motion. Human and animal brains are similar.

Lavater J

He lived 1741 to 1801.

Bell C

He lived 1774 to 1842, studied reciprocal innervation and haptic perception, and related muscles to facial expressions. Spinal-nerve anterior and posterior roots have separate functions {Bell-Magendie law, Bell}: dorsal root is sensory, and ventral root is motor [1822].

Gall F

He lived 1758 to 1828, founded phrenology, and studied brain white matter, gray matter, and ganglia.

Purkinje J

He lived 1787 to 1869 and studied brain neurons. He said fingerprints are unique [1823]. As light intensity decreases, red objects fade faster than blue objects {Purkinje effect} [1825]. He discovered germinal vesicles [1825], skin sweat glands [1833], Purkinje cells [1837], and Purkinje fibers [1839]. He digested protein with pancreatic extract [1836].

Flourens M

He lived 1794 to 1867, studied brain and concluded that cortex acts as one unit, and ablated brain areas to investigate brain function. Cerebellum is for muscle coordination. Medulla is for respiration. Central nervous system has diverse and localized psychological functions.

Baer K

He lived 1792 to 1876 and discovered ovum in mammals [1826]. Embryos of various vertebrates are similar {Baer laws}.

Quetelet L

He lived 1796 to 1874 and developed social and human statistics.

Braid J

He lived 1795 to 1860 and studied how to induce hypnosis.

Broca P

He lived 1824 to 1880, developed skull-measuring instruments, and studied prehistoric skull trephining. He first described Cro-Magnon and Aurignacian man. He disproved theory {Celtic myth} that Celts constituted a racial group with inherited characteristics [1866]. Frontal-lobe-third or inferior-gyrus damage {Broca's area, Broca} makes people unable to speak [1861].

Duchenne G

He lived 1806 to 1875 and located innervated muscles for behaviors, gestures, and expressions. He studied locomotor ataxia and tried electrical stimulation therapy.

Miescher F

He lived 1844 to 1895 and discovered DNA in trout sperm [1869]. Blood carbon dioxide level regulates breathing.

Fritsch Hitzig G

Fritsch lived 1838 to 1927. Hitzig lived 1838 to 1907. They studied Broca's-area localized motor functions.

Golgi C

He lived 1843 to 1926 and found Golgi cells [1883] and Golgi apparatus [1909]. If silver chromate stains neural tissue, some nerve cells stain black and become visible among unstained, transparent cells [1873].

Ramon y Cajal S

He lived 1852 to 1934 and studied neurons and brain microscopic structure. Nerve signal goes from neuron axon to next-neuron dendrite.

Flechsig P

He lived 1847 to 1929. Cortex association areas myelinate after birth, while sense and motor areas myelinate before birth.

Sherrington C

He lived 1857 to 1952, named neuron junctions "synapses", showed that transmission slowed there, and studied antagonistic-muscle reciprocal innervation. He studied peripheral and spinal reflexes, including dog scratch reflex, and relations between reflexes and behavior patterns.

He studied sense exteroceptors, interoceptors, and proprioceptors. Exteroceptive distance receptors detect movements and are at animal leading edges. Distance receptors receive stimuli far from physical source. Brains can build space-time relations to represent environment. Interoceptive receptors receive stimuli where physical sources contact body surface. Proprioceptive receptors receive stimuli from inside body.

Precurrent receptors initiate behavior, and non-precurrent receptor activity stops behavior. Behavior relies on body hierarchical spatio-temporal subsystems that evolution built and linked for survival. Body-limit perception affects behavior.

Organisms evolved to allow more exploration and autonomy, as distance receptors and brain integration evolved. Organisms had more prey and predator knowledge. Anticipatory responses extended control over space and time, so reaction time increased and immediate receptor responses lasted longer.

Brodmann K

He lived 1868 to 1918 and mapped 52 cortical areas [1903 to 1908].

Barany R

He lived 1876 to 1936 and studied ear labyrinth functions.

Flexner A

He lived 1866 to 1959. He studied polio [1910].

Holmes G

He lived 1876 to 1965 and studied sensation locations and spinal and head injuries. He found Adie's syndrome and Holmes' syndrome [1941], with William Adie.

Riddoch G

He lived 1888 to 1947. He studied brain injuries [1917]. Blind patients, with V1 area damage, can consciously perceive fast moving highly contrasting stimuli {Riddoch syndrome}.

Henschen S

He lived 1847 to 1930. Occipital lobes have topological maps [1919]. People can lose ability to calculate but retain other abilities.

Head H

He lived 1861 to 1940 and studied cerebral cortex and sensation. Cortical memory stores flexible experience representations {schema, Head}.

Hess W

He lived 1881 to 1973. Hypothalamic stimulation causes emotions and controls internal organs [1928].

Dodge R

He lived 1871 to 1942 and studied human variation.

Moniz E

He lived 1875 to 1955 and started frontal lobotomy for mental illness [1935].

McCulloch W

He lived 1899 to 1972 and studied chimpanzee isocortex. He invented Perceptrons, with Walter H. Pitts. Neuron model sends unit output if input is above threshold. Finite device combinations, including loops, can perform any algorithm. Neural networks can recognize figures, so any input feature from figure produces same output. Reliable neural networks can come from unreliable components using redundancy.

Eccles J

He lived 1903 to 1997 and studied cerebellum [1967]. Connections between sense and motor nerves in spinal-cord gray matter are responsible for reflexes [1951]. Matter and mind are separate substances, and interact in synapses {interactionism, Eccles}. Mind has units {psychon, Eccles}.

Tjio J

He lived 1919 to ?. Human chromosome number is 46, rather than 44 or 48 [1955].

Reichardt W

He lived 1924 to 1992 and developed neuron motion-detector models, to explain how flies detect motion.

Brain R

He lived 1895 to 1966 and studied brain.

Lettvin J

He lived 1920 to ?. Axons from frog retinal ganglion cells have four groups that respond differently to different stimuli and that end in four distinct optic-tectum layers, all with same topographic map. Frog is normally motionless, so detectors detect environment changes.

Sustained contrast detectors make immediate and prolonged signals when object edge, either lighter or darker than background, moves into receptive field and stops.

Net convexity detectors make immediate and temporary signals when large dark-object small or convex edges pass through visual field. Smooth movement has less effect than jerky movement.

Moving-edge detectors respond to edges moving through receptive field. Net dimming detectors make immediate and prolonged signals with sudden illumination reduction. Frogs can recognize prey and enemy categories.

Heimer L

Heimer lived 1930 to 2007.

Barlow H

He studied frog-retina bug-detector ganglion cells. Thousands of cardinal cells code percepts [Barlow, 1972] [Barlow, 1995]. Qualia are not basic phenomena but brain-developed sensations that depend on memory and processing. Consciousness comes from social communication.

Szentagothai Arbib

They studied brain and neural networks.

Eccles Ito Szentagothai

Szentagothai lived 1912 to 1994.

Bullock Orkand Grinnell

.

Weale R

He studied vertebrate eye.

Adrian R

He lived 1927 to ?.

Caplan D

.

Reichardt Poggio

.

Alkon D

.

Aoki Siekevitz

.

Black I

.

Peters Palay Webster

.

Calvin W

Brain works by selection. 0.5-mm-diameter cortical hexagonal columns and their lateral connections represent symbols. Columns vary, compete, and replicate. Symbols integrate and coordinate to make scenes and help each other compete and copy. Consciousness is image or scene that is most populous {scenario spinning}.

Thomson Ja biology

He discovered embryonic stem cells [1998].

Cotterill R

Perhaps, consciousness is in anterior cingulate. Consciousness unifies body actions. Perhaps, ability to make new reflexes is consciousness purpose. He developed computer simulations (CyberChild) to find neural correlates of consciousness. It uses mammalian nervous system circuits grouped into binary composite units. It has two senses, hearing and touch. It controls vocalization, feeding, and bladder-control muscles. It has pain receptors for low stomach-milk level, low blood-sugar level, full bladder, and dirty diaper. Emergent behavior, such as ability to make new reflexes, indicates consciousness.

Carter R

Brain scans associate brain regions with psychological functions.

Waxman S

.

Cleeremans A

Consciousness unifies by integrative processes among brain parts.

4-Biology-History-Behavior

Burgess Thom

Experiment cannot induce blushing physically. Experiment can induce blushing only mentally. Trying to restrain blushing only increases it.

Bates H

He lived 1825 to 1892, studied mimicry [1862] {Batesian mimicry}, and was a naturalist in Amazon [1848 to 1859].

Donders F

He lived 1818 to 1889 and studied eyes and reaction times.

Charcot J

He lived 1825 to 1893 and studied multiple sclerosis, hysteria, hypnosis, and tabes dorsalis "shooting pains" {lightning pains}.

Pfluger E

He lived 1829 to 1910. Organisms have goal-directed feedback mechanisms to stabilize output.

Romanes G

He lived 1848 to 1894. Animals learn by imitation [1886].

Loeb J

He lived 1859 to 1924. Simple animals have forced tropism movements. Animals move towards stimulus source {positive tropism} or away from it {negative tropism}. Simple animals have paired receptors, such as eyes, which send signals to paired muscles, such as legs. When both receptors send equal signals, tension balances between both muscles, and animal moves in straight lines {tonus hypothesis}. However, tonus hypothesis is not true for simple or higher animals.

Lorenz K

He lived 1903 to 1989 and studied natural behavior {ethology, Lorenz}, aggression, imprinting, instincts, innate releasing mechanisms, and fixed action patterns.

Tinbergen N

He lived 1907 to 1988 and studied ethology.

Masters Johnson

Masters lived 1915 to 2001. Johnson lived 1925 to ?. They studied sexuality.

Brown B

People can sense unconscious body behavior by signal biofeedback [1968]. After training, people can control one neuron or can change blood pressure or heartbeat.

Goodall J

She lived 1934 to ? and studied chimpanzee behavior. Chimps grunt, pant, bark, roar, scream, squeak, whimper, laugh, click teeth, and smack lips, in 30 different ways with different meanings [1972].

Napier John R biology

He lived 1917 to 1987.

Seyfarth Cheney

Monkeys make alarm calls even when they can perceive that other monkeys are not near or that other monkeys are calling already. Monkeys do not have theory of mind. Vervet monkeys make different alarm calls for eagles, leopards, and snakes and use grunts in social interactions.

4-Biology-History-Biochemistry

Berzelius J

He lived 1779 to 1848 and discovered proteins [1838] and studied ions and atomic and molecular weights. He invented old chemical symbols [1811] and atomic-weight table [1826].

Kirchhoff Go

He lived 1764 to 1833 and discovered enzymes. Wheat gluten enzyme converts starch to sugar and dextrin [1812].

Wohler F

He lived 1800 to 1882 and synthesized urea from ammonium cyanate [1828], the first artificial organic-chemical synthesis.

Liebig J

He lived 1803 to 1873 and described enzyme action chemically {law of the minimum}. He observed that plants use nitrogen and carbon dioxide from air. He invented nitrogen fertilizer. He invented {Liebig condenser}. He silvered mirrors [1835]. He invented beef extract [1865].

Michaelis L

He lived 1875 to 1940 and studied enzyme kinetics and analyzed enzyme-substrate complexes as chemical equilibria.

Menten M

She lived 1879 to 1960 and studied enzyme kinetics and analyzed enzyme-substrate complexes as chemical equilibria.

Van Niel C

He lived 1897 to 1985 and studied anaerobic photosynthesis [1931].

Krebs H

He lived 1900 to 1981 and studied tricarboxylic carbohydrate cycle [1937].

Luria S

He lived 1912 to 1991 and studied enzymes [1938 to 1965].

Kornberg A

He lived 1918 to ? and synthesized DNA molecules using DNA polymerase I [1955 to 1958].

Brenner Meselson Jacob

Brenner lived 1927 to ?. Meselson lived 1930 to ?. Jacob lived 1920 to ?.

Hodgkin D

She lived 1910 to 1994 and determined insulin structure.

Khorana G

He lived 1922 to ? and synthesized yeast gene [1960].

Arber W

He lived 1929 to ?.

Lane D

TP53 gene kills cell if cell has broken DNA or has low oxygen, by making p53 protein [1979].

Botstein Davis Skolnick

.

Cech Altman

They found ribozyme RNA that can act as enzymes to cut other RNA [1982]. RNA was first molecule able to replicate, because RNA can be catalyst. DNA bases and sugars came from RNA bases and sugars. For example, thymine can come from uracil. RNA works with ribosomal proteins, amino acids, and many enzymes.

Baltimore D

He studied RNA viruses [1985].

4-Biology-History-Botany

Burbank L

He lived 1849 to 1926 and developed new plant varieties.

Carver G

He lived 1864 to 1943 and developed soil improvements and new peanut, soybean, and cotton uses. He rotated peanuts with cotton.

4-Biology-History-Development

Harvey Wi

He lived 1578 to 1657 and studied embryology. Blood flows through blood vessels from and to heart.

Haeckel E

He lived 1834 to 1919 and studied marine invertebrates. Ontogeny recapitulates phylogeny {theory of recapitulation}. Sperm are mostly nucleic acid [1868].

Driesch H

He lived 1867 to 1941. Cell from 2-cell, 4-cell, 8-cell, or 16-cell frog embryo can develop into complete adult, which can spawn complete children [1895]. Cell non-material transcendental order moves animal development toward adulthood {entelechy, Driesch}.

Thompson D

He lived 1860 to 1948. Dynamical forces and energies make a few main growth and development patterns and determine organism shapes.

Humphrey N

He studied brain development from social interactions. People {natural psychologist} talk to themselves to think what to do in different social situations and so understand, predict, and control what other people do. People then evolved systems {inner eye} to image brain processes and states. Such imaging is consciousness. Consciousness emerged abruptly as existing features combined. Sensations are actions and their thoughts.

Wolpert L

He lived 1929 to ?.

Winick M

.

Alexander R

He studied brain development from social interactions.

McGinnis W

Hox regulatory genes govern fruitfly development [1983].

Harris H

MYC, BCL-2, APC, and RAS genes check cell division [1985].

Selkoe D

.

Shatz C

.

4-Biology-History-Ecology

Berger H

He lived 1873 to 1941 and invented electroencephalogram [1924]. Electrodes can measure scalp electrical potentials {electroencephalography, Berger}. Alpha waves are regular 10-Hz oscillations that happen when people relax and close their eyes. Beta waves are faster and less synchronous oscillations that replace alpha waves when people perform mental activity and keep their eyes open.

Eiseley L

He lived 1907 to 1977 and studied ecology.

Commoner B

He lived 1917 to ? and studied ecology and population. He opposed above-ground nuclear testing [1952].

4-Biology-History-Evolution

Linnaeus C

He lived 1707 to 1778, classified plants and animals by structures, and named organisms as genus and species {binomial nomenclature, Linnaeus}.

Trembley A

He lived 1710 to 1784 and related hydra and jellyfish. Hydra and jellyfish parts can move and bud.

Cuvier G

He lived 1769 to 1832 and studied fossils, differentiated animals by body structures and nervous systems, and noted adaptations to environment.

Saint-Hilaire E

He lived 1772 to 1844 and studied fossils and compared fish and land animals, vertebrates and insects, and cephalopods and vertebrates. Fossils have structure homologies {unity of type}. Body type depends on vertebral structure.

Agassiz L

He lived 1807 to 1873. Species form hierarchies, with form laws {taxonomy, Agassiz}.

Owen R

He lived 1804 to 1892 and found horse intermediate fossils. All vertebrates have body plans based on repeating vertebrae, which can evolve.

Darwin C

He lived 1809 to 1882. He developed plant and animals evolution theory. Natural selection of variations leads to the most-successful reproduction {survival of the fittest, Darwin}. Species evolved from earlier species, making branching evolutionary trees. Evolution has caused changes without needing causer. Evolution has support from organism location, because similar environments in different locations have different organisms, and similar, mutually accessible, locations with different environments have similar organisms. Evolution has support from comparative anatomy, because different species have similar hand bones, and species have vestigial structures. Evolution has support from embryology, because segmented-worm and unsegmented-mollusc larvae are similar, and vertebrate embryos have gills. Evolution has support from the fossil record, which shows intermediate forms. Changes have billions of years to happen. Ancient rocks and environment differ from now, and fossil life forms differ from now. Current animals adapted to present environment, not to ancient one. Finches of Galapagos Islands and barnacles were test cases.

He also studied emotions. Human emotional-response and facial-expression origins are pre-human species behaviors.

Wallace A

He lived 1823 to 1913 and independently developed evolution theory with survival of fittest. He studied animal geography and life in Amazon River basin and Malay Archipelago.

Volterra V

He lived 1860 to 1940 and studied integral equations [1883]. Mating, dying, or other-species effects cause predator-number and prey-number change rates {Lotka-Volterra differential equations, Volterra} [1926]. In ecosystems, predator and prey numbers can oscillate until reaching steady state, can continue to oscillate, or can become zero, so species is extinct.

Dart R

He lived 1893 to 1988 and found Taung child, Australopithecus africanus [1924].

Lotka A

He lived 1880 to 1949. Mating, dying, or other-species effects cause predator-number and prey-number change rates {Lotka-Volterra differential equations, Lotka} [1926]. In ecosystems, predator and prey numbers can oscillate until reaching steady state, can continue to oscillate, or can become zero, so species is extinct.

Yerkes R

He lived 1876 to 1956 and studied primates [1929 to 1943].

Wright S

He lived 1889 to 1988 and discovered genetic drift. Species arise randomly even within clade that has evolutionary direction {Wright's rule}. Selection changes allele frequencies.

Huxley J

He lived 1887 to 1975 and developed cladistics. Organism characteristics are clade units that determine classes and hierarchies. Organisms have homologies, and cladogram nodes represent shared homologies. Cladistics can use property absences.

Dobzhansky T

He lived 1900 to 1975 and studied evolutionary theory.

Waddington C

He lived 1905 to 1975 and studied evolution [1939].

Mayr E

He lived 1904 to 2005 and examined differences between historical and non-historical sciences. New species result from variety geographic isolation {allopatry, Mayr} [1960 to 1970], rather than arising in same location {sympatry, Mayr}.

Lysenko T

He lived 1898 to 1976 and opposed evolution by natural selection.

Leakey L

He lived 1903 to 1972 and found fossil hominins [1949 to 1959].

Eigen M

He lived 1927 to ? and developed relaxation methods, to measure 10^-10 second reaction rates [1954]. High mutation rates prevent natural selection [1992].

Duve C

He lived 1917 to ? and discovered lysosomes [1955] and peroxisomes [1965].

Hamilton W biology

He lived 1936 to 2000. Sexual reproduction results from competition between parasite and host [1963].

Woese C

He lived 1928 to ?. Small subunit ribosomal RNA can classify organisms [1965].

Williams Ge

Genes are natural-selection units, and organisms passively contain them. Evolution changes gene frequency and can make new genes.

Dubos R

He lived 1901 to 1982 and studied evolution.

Eldridge N

New speciation is at range fringes in isolated places. Species change little at other times.

Smith Jo biology

He lived 1920 to 2004 and studied population-biology relations {logistic difference equation, Smith}.

Margulis L

Early bacteria incorporated into eukaryotes to make mitochondria and chloroplasts {endosymbiont hypothesis, Margulis} [1970].

Thomas L

He lived 1913 to 1993.

Leakey R

He discovered genus Homo fossils [1974].

Beer G

He lived 1899 to 1972.

Wilson E

He invented sociobiology.

Dawkins R

Ideas or concepts {meme} {mimeme} can exist in brain, replicate, and have selection. Thoughts and ideas in memory or culture replicate themselves in other minds by imitation and transmission. Memes compete for entry into minds. Selective forces act directly on meme physical substrates, because memes restructure brains to make better habitats for themselves and to modify input and output. Perceptions, skills, feelings, and memories have no copies.

Meme sets {memeplex, Wilson} {co-adapted meme complex} can affect survival and reproduction [Dawkins, 1976]. He wrote about Universal Darwinism and replicators [Dawkins, 1995].

Meme copies behavior from another same-species animal {imitation, Dawkins}, but copying varies more than for genes. Memory ties abstractions and agreements together, so imitation is only small part. However, copy does not have same meaning, because brain does not just imitate but processes information. It involves selection and non-selective processes.

Culture also involves sharing knowledge {schema, Dawkins}, not by imitation but by abstraction. Culture also involves sharing beliefs and values {social construction}, not by imitation but by agreement. Culture depends on having a theory of mind and knowing that other people have beliefs, intentions, and desires. Genes {selfish gene} use bodies to reproduce themselves.

Gould S

Evolution repeats and modifies animal forms {bauplan, Gould}. Evolutionary changes can be in bursts {punctuated equilibrium, Gould}, even after 20,000 years with no change. Most traits are side effects. Timing changes during development cause evolutionary changes.

Organisms produce more offspring than survive to reproduce {superfecundity, Gould}. Darwin defended this idea against people that thought God is more benevolent. Offspring vary in traits. All accept this idea. Offspring pass their traits to offspring. All accept this idea. Therefore, offspring with traits more favorable for survival to reproductive age will produce more offspring with same traits {natural selection, Gould}.

Darwin's evolutionary theory has three main principles to explain natural-selection mechanisms. Natural selection applies to organisms, not classes, genuses, species, tissues, organs, or genes.

Darwin suggested that altruism in humans was trait outside this idea. Perhaps, altruism can explain hybridization and worker-insect sterility. Modern theory suggests genes, cell lines, organisms, demes, species, and clades evolve using selection and drift to change frequencies and parts. They can work synergistically, in opposition, or independently of nearby levels. Other possibilities can be entropy effect or complex system spontaneous ordering.

Natural selection removes unfit and designs fit, because variations from typical or average are small, random, and numerous and not always negative. Small and large variations accumulate over many generations. Variations can have different kinds and sizes {microevolution, Gould}. Modern theory adds structural, historic, and developmental factors. Natural selection gradually makes more-complex organisms and can make new higher-level organism species. However, modern theory adds mass extinctions, species sorting by punctuated equilibrium to alter clades, and other processes taking different times. Other possibilities can be inorganic and organic comparisons or new species-formation ideas.

Because organisms overproduce, nature has competing organisms and species, so new ones must replace or wedge aside existing ones, leading to better-adapted species. This requires that environment changes slowly compared to evolution and observed species changes.

Interactors, rather than replicators, can define selection. Emergent fitness, rather than emergent traits, causes higher-level selection. Species selection is main macroevolution method.

Evolutionary theory involves same framework as other scientific explanations. It involves causation vs. association. Event sequences relate or do not relate. Related events are consequences or not. Structures and functions exist. Logical conclusions come from premises. People can find causation direction. Determinism comes from fundamental-unit laws versus independent-level interactions. Changes are gradual, spurt, maintain stasis, are exponential, or rise and fall. It involves fundamental units, structure hierarchies, change rates, space scales, and time scales.

Darwin felt that nature had progressed, because organism and ecosystem design was good (Paley) and complexity was increasing. Besides, nature ordered itself in the most-efficient way by survival of fittest (Adam Smith).

Increased speciation leads to increased extinction.

Clade selection, species habitat tracking, and grouping in populations can cause stasis.

Organisms tend to evolve to larger size, from individual size advantages and structural factors {Cope's rule, Gould}.

Slow variation and slow environmental change helped ancient organisms alive today survive. Their clades had low speciation.

Clades have various speciation rates, which can change over time and mimic seemingly progressive linear species changes, as in horses and humans.

Humans are stable genetically if punctuated equilibrium is true.

Drift can go into available niches, but bacteria dominate life.

Geometric patterns and physical laws, such as surface-to-volume ratios and coordinate transformations, constrain structures and allow few alternatives. Historical development can impose homologies and regulations. Adaptation consequences {exaptation, Gould} can have later advantages.

Homology is internal structure similarity {homogeny, Gould}. Homology can result from fundamental internal structure {parallelism, Gould} or same external pressures {convergence, Gould}. Organisms can also perform similar functions with different structures {homoplasy, Gould}.

Darwin held that small structure shifts were adaptive, but cumulative-shift adaptations can be different {functional shift, Gould} {cooptation, Gould}. Initial stages have unpredictable uses, constrain future adaptation, and form sequence. Non-adaptive structures {spandrel, Gould} arise in association with adaptive structures, and these structures can later be for adaptation, at all hierarchy levels. Adaptive structures tend to limit further evolution through specialization, but adaptive structures make many more non-adaptive structures with which evolution can work.

Bone Q

.

Kimura M

Gene DNA evolves at constant rate in all species over all history. Molecular changes that have less control by natural selection evolve more rapidly, because they have no effects, while harmful ones die out and good ones are rare {Kimura's rule}.

Cavalli-Sforza L

He studied human gene frequencies, race, and population migrations.

Raup D

Catastrophe has happened at mass-extinction level, and clades, species, demes, organisms, cell lines, and genes can have extinctions {field of bullets model}.

Ewald P

Infections that use intermediate hosts, such as cholera and malaria, evolve to be stronger [1993]. Infections that infect directly evolve to be weak enough to maintain the host. Infections cause most genetic and chronic diseases.

Ridley M

.

Tattersall I

He studied human origins from hominins [1997].

Allman J

He studied brain evolution. Brains allow animals to account for environment variations in space and time and make appropriate responses. More advanced brains allow wider spaces and longer times. Brains require much energy and are in animals that can find more and/or better food at higher rate. Complex brains require longer time to develop. Family and group structures were necessary for humans to have advanced brains.

Brains can sense water, food, sexual partners, shelter, and safe locations, as well as predators and dangerous locations. Brains can assign priorities to input. Brains can perform activities to get food or water, reproduce, gain shelter and safe locations, and avoid predators and dangerous locations. Brains can remember input and output.

Brains are more complex if environmental niche is more variable. Animals use larger energy amounts, because warm-blooded. Water, food, sexual partners, shelter, and safe locations are scarcer and predators and dangerous locations are more numerous. Maximize age is higher.

4-Biology-History-Genetics

Mendel G

He lived 1822 to 1884 and developed Mendel's inheritance laws by studying dominant and recessive characteristics of pea-plant independent and discrete heredity units.

Galton F

He lived 1822 to 1911 and studied human mental-property and physical-property genetics. He collected and classified fingerprints {fingerprinting}. He studied human individual differences, using imagery, psychological questionnaires, twin life histories, and family and talented-people educational backgrounds. He developed the correlation coefficient. He participated in scientific exploration to unexplored Africa.

He discovered air pressure systems and invented weather maps [1875]. He invented a polyhedron {Galton's Polyhedron} of possible structural forms to which organisms can jump. More intellectually gifted people have less vivid imagery [1883].

Flemming W

He lived 1843 to 1905 and studied mitosis [1870], meiosis, and chromatin role [1879].

Weismann A

He lived 1833 to 1914. Specialized cells carry genetic information {germ line} {germ plasm theory} [1883]. Selection can operate at levels below and above organisms.

de Vries H

He lived 1848 to 1935, studied evening-primrose mutations [1900], and developed inheritance laws based on cell factors {pangenesis, de Vries} [1889]. Plants can jump from form to form, unconstrained by structures. Phylogenesis results from species selection.

Bateson W

He lived 1861 to 1926 and invented the word genetics for heredity study. Genes carry genetic information and are in chromosomes. New species come from repeated-body-segment structure and number changes. Such modifications can lead to similarity with existing part {homeosis, Bateson}. Parts can have jumps. For example, upper thoracic vertebrae can have no ribs or lower cervical vertebrae can have ribs.

Janssens F

He lived 1863 to 1924 and studied crossing-over.

Morgan T

He lived 1866 to 1945, studied gene linkage, and invented linkage maps, using fruit flies [1909 to 1915]. Genes are in chromosomes.

Garrod A

He lived 1857 to 1936 and studied genetics [1909].

Fisher R

He lived 1890 to 1962. He developed statistical-significance methods {analysis of variance, Fisher} and Fisher experiment-design theory [1920]. Mendelian inheritance in large populations with great variety can result in gradual evolution, but blending inheritance does not work. Variation frequency varies inversely with variation magnitude. Natural selection can increase allele frequency.

Muller H

He lived 1890 to 1967. X-rays mutate fruitfly cells [1926]. Many mutations cause cancer [1951].

Goldschmidt R

He lived 1878 to 1958 and studied gypsy moths. Genes {rate gene} can control rates and regulate other genes.

Beadle G

He lived 1903 to 1989. One gene makes one protein [1941].

Tatum E

He lived 1909 to 1975. One gene makes one protein.

Avery O

He lived 1877 to 1955. DNA transfers from cell to cell in chromosomes. DNA contains gene information to transform cells. He studied pneumococcus deadly S strain, with smooth surface, and mild R strain, with rough surface.

Simpson G

He lived 1902 to 1984. DNA transfers from cell to cell in chromosomes. DNA contains information to transform cells.

McClintock B

She lived 1902 to 1992 and studied corn transposable elements {jumping gene, McClintock} [1951].

Franklin R

She lived 1920 to 1958 and performed x-ray crystallography of DNA indicating it was double helix [1953].

Watson Ja

He lived 1928 to ? and calculated that DNA was double helix [1953].

Crick F

He lived 1916 to 2004 and calculated that DNA was double helix [1953]. Perhaps, consciousness depends on thalamus and cortex layers 4 and 6 [1994].

Monod J

He lived 1910 to 1976 and studied DNA repression and expression in Lac operon [1961].

Nirenberg M

He lived 1927 to ? and found DNA and RNA triplet code [1962].

Brinster R

He lived 1932 to ?, cloned foreign genes, and expressed repressed genes in mice [1974].

Wall Leder

Genes rearrange themselves in early infancy [1978]. Antibody genes can join joining gene by deleting DNA between them. Joining genes join to trunk genes, which determine mobility level. Joined genes determine antigen.

Brenner S

He lived 1927 to ? and helped determine worm and human genetic codes [1982].

Scheller Axel

.

Capecchi Smythies

They invented gene knockouts in mice [1990].

Venter C

He organized scientists to sequence a free-living organism [1995] and the human genome [2001]. Haemophilus influenzae bacterium has 1000 genes with 1,800,000 bp.

Waterston Sulston

They organized scientists to sequence C. elegans animal genome [1998].

Rogers Gibbs

They organized scientists to sequence mouse genome.

4-Biology-History-Immunology

Burnet M

He lived 1899 to 1985 and suggested clonal-selection theory.

Medawar P

He lived 1915 to 1987 and studied immunology.

4-Biology-History-Invention

Cheselden W

He lived 1688 to 1752, developed artificial pupil, and removed kidney stones {kidney stone removal} and cataracts.

Jenner E

He lived 1749 to 1823 {smallpox vaccine}.

Helmholtz H

He lived 1821 to 1894 and founded perceptual physiology {ophthalmoscope, Helmholtz}. He developed Young-Helmholtz trichromatic color-vision theory and studied lens accommodation. He first timed nerve-signal conduction rate and muscle-action times [1850]. Speed at which electrical impulses travel along nerve fibers limits human reaction time. Pitch discrimination depends on resonance {fixed pitch theory}.

Epistemology

People cannot know external physical events and only have neural signals. Neural signals from senses gain meaning from learned associations, which depend on assumptions that can be incorrect. Perceptions are unconscious inferences. People cannot experience or introspect how they perceive or think. People cannot know data on which brain bases perceptions and beliefs. During perceptions and decisions to perform muscle movements, nerve signals switch. Body sense receptors receive and analyze physical energies from outside world to make independent, simple, and unnoticeable sensations, and brains learn to perceive objects and events that probably produced sensations {classical theory of psychology}.

Laval C

He lived 1845 to 1913.

Harrison R

He lived 1870 to 1959 {tissue culture}.

Bekesy G

He lived 1899 to 1972. Sound vibrations travel from one inner-ear basilar-membrane end toward the other [1928 to 1932]. For sound frequencies, different membrane positions have maximum vibration.

Sanger F

He lived 1918 to ?, determined insulin amino-acid sequence [1950], and developed method to sequence DNA [1977].

Grey Walter W

He lived 1910 to 1976 and studied body electrical behavior {toposcopy}, muscle contraction, electroencephalograms, electroconvulsive therapy, frequency analysis, and evoked potentials. He implanted brain electrodes to study epilepsy and treat psychiatric illness in conscious humans.

Brain-function electromechanical models, with two control systems and several interacting units, can produce life-like behavior, including learning, as in electromechanical tortoise called M. speculatrix.

Brain electrical potential has negative shift between associated stimuli just before decision becomes public {contingent negative variation} (CNV). Motor cortex sends output before people act [Walter, 1953]. Helical scanner measures and displays frequencies and phases on short time-scales from many brain electrodes.

Salk J

He lived 1914 to 1995 {polio vaccine}.

Sabin A

He lived 1906 to 1993 {oral polio vaccine}.

Shine J

He found Shine-Dalgarno sequence [1961].

Cohen Boyer

Cohen lived 1922 to ?. Boyer lived 1936 to ?.

Milstein Kohler

They started gene engineering {genetic engineering}.

Maxam Gilbert

They developed method to sequence DNA [1977].

Mullis K

Polymerase chain reaction (PCR) developed to make multiple copies of DNA.

Jeffreys A

He studied human identification {DNA fingerprinting, Jeffreys}.

French Wi

Successful therapy {gene therapy, French} treated adenosine deaminase deficiency {adenosine deaminase deficiency} (ADA).

Wilmut I

He cloned Dolly the sheep from adult sheep cells {mammal cloning}.

4-Biology-History-Medicine

Tabari A doctor

He lived 838 to 923.

Syndenham T

He lived 1624 to 1689 and described diseases accurately. Hysteria in women and hypochondrias in men are similar. Hysterical symptoms often accompany depression. He invented opium tincture {laudanum, Syndenham} [1660].

Semmelweis I

He lived 1818 to 1865 and started hand washing in chlorine solution [1847].

Pasteur L

He lived 1822 to 1895 and studied yeast and fermentation [1855], developed pasteurization [1864], and developed rabies vaccine [1883]. Organic molecules can have chirality. Cells come from cells, with no spontaneous generation.

Virchow R

He lived 1821 to 1902 and studied cell theory. Cells arise from each other over continual generations {Omnis cellula e cellula}.

Lister J

He lived 1827 to 1912, used carbolic acid on wounds to prevent infection [1866], and studied bacteria, antiseptics, heat sterilization, and operative techniques [1877].

Ferrier D

He lived 1843 to 1928 and developed operations to treat brain injuries and diseases. Cerebral functions are in fixed brain areas.

Wernicke C

He lived 1848 to 1905, studied sensory aphasia and word-usage and word-choice disorders, and invented language brain-flow diagrams. Alcoholics often have thiamine deficiency, which can cause encephalopathy.

Koch R

He lived 1843 to 1910, stained bacteria [1877], grew bacterial colonies [1890], studied anthrax [1876], tuberculosis, and cholera, and developed tuberculin test [1890]. He developed Koch's postulates about disease.

Breuer J

He lived 1842 to 1925, studied hysteria using hypnosis, and discussed catharsis. Vagus nerve controls breathing. Semicircular canals are for balance.

Jackson J

He lived 1835 to 1911. He noted focal-epilepsy involuntary-movement sequences and deduced motor-cortex excitable-area spatial patterns. Patients can utter words or phrases under stress or during high emotion, though they cannot speak voluntarily.

Krafft-Ebing R

He lived 1840 to 1902 and studied syphilitic infection, which can cause insanity and paralysis.

Mayo Mayo

Charles lived 1865 to 1939. William lived 1861 to 1939. They performed surgery at Mayo Clinic [1889].

Ehrlich P medicine

He lived 1854 to 1915. He used methylene blue as antimalarial drug [1891], trypan red and trypaflavin against trypanosomiasis, acriflavine as antibacterial, arsenical compounds (Carbarsone) against amoebas, arsenical compounds (Salvarsan and oxophenarsine) against syphilis bacteria [1907 to 1909]. He discovered drug resistance [1925].

Breinl Thomas

Breinl lived 1880 to 1944 {sleeping sickness, drug}. Atoxyl kills trypanosomes [1905], which cause human trypanosomiasis. Thomas studied yellow fever.

Rous P

He lived 1879 to 1970 and discovered first oncovirus, Rous sarcoma virus [1909].

Franz S

He lived 1874 to 1933 and studied focal cerebral-cortex lesions, frontal-lobe functions, motor-center variability, and aphasia.

Cannon W

He lived 1871 to 1945 and studied psychosomatic disease and fear and rage biochemistry. Body maintains chemical and function equilibrium {homeostasis, Cannon}. Body uses feedback signals to indicate needs and to initiate action to obtain needs.

Fleming A

He lived 1881 to 1955. Penicillin is antibacterial drug [1928].

Penrose L

He lived 1898 to 1972 and studied mental deficiency and genetics of Down's syndrome and epiloia or tuberous sclerosis. Maternal age increases children's Down's syndrome, but paternal age does not. Subnormality is not qualitatively different than normal intelligence. Mental deficiency has many factors and causes, and people can perform well on some factors. Mental deficiency is more common in parents and relatives of people with IQ 50 or above than it is in parents of people with IQ lower than 50.

Lima A

He performed prefrontal lobe leucotomy to cure chronic anxiety, depression with suicide risk, and obsessive-compulsive disorder [1935].

Penfield W

He lived 1891 to 1976, studied local epilepsy, found epileptic brain-lesion locations and extents [1938], and surgically treated local epilepsy. He electrically stimulated brains to find regions needed for language, but he also elicited images and sensations, which are same dream-like sensations that patients experience when epileptic [Penfield, 1975] [Penfield and Perot, 1963]. Removing tissue did not delete sensation.

Spock B

He lived 1903 to 1998.

Kinsey Pomeroy Martin

Kinsey lived 1894 to 1956. Pomeroy lived 1913 to 2001. Martin lived 1918 to ?. They studied sexual physiology and behavior.

Ingram V

He lived 1924 to 2006. One amino-acid change in hemoglobin causes sickle cell anemia [1956].

Marshall Warren

Helicobacter pylori bacteria cause ulcers [1982].

Prusiner S

Misshapen prion proteins cause scrapie [1982].

Gallo Montagnier

DNA sequence of HIV published [1985].

Weinberg R

He found first tumor suppressor gene, RB gene [1986].

Gershan Rieder

.

4-Biology-History-Microbiology

Escherich T

He lived 1857 to 1911.

Twort F

He lived 1877 to 1950. Félix d'Hérelle discovered it in 1917.

4-Biology-History-Naturalists

Muir J

He lived 1838 to 1942 and wrote about the beauty and meaning of nature, especially after visiting Yosemite [1868].

Burroughs J

He lived 1837 to 1921.

Crutch J

He lived 1893 to 1970.

4-Biology-History-Origin Of Life

van Helmont J

He lived 1577 to 1644. Plants make organic materials and do not get them from soil, which stays same weight while plant grows.

Redi F

He lived 1626 to 1697 and proved spontaneous generation does not happen, by showing that maggots did not come from meat [1668].

Schleiden M

He lived 1804 to 1881 and invented plant cell theory. Cells are life units.

Schwann T

He lived 1810 to 1882 and invented animal cell theory. Cells are life units.

Haldane JBS

He lived 1892 to 1964. In atmosphere or ocean, ultraviolet radiation, volcanic heat, lightning, and radioactive-nuclei ionizing radiation can make complex organic molecules from nitrogen, methane, ammonia, water, carbon dioxide, and hydrogen {Oparin-Haldane hypothesis, Haldane}.

Oparin A

He lived 1894 to 1980. Glycerin molecules mixed with other molecules can clump together to make stable gel coascervates [1926]. Other molecules can enter, interact inside, and leave glycerin. In atmosphere or ocean, ultraviolet radiation, volcanic heat, lightning, and radioactive-nuclei ionizing radiation can make complex organic molecules from nitrogen, methane, ammonia, water, carbon dioxide, and hydrogen {Oparin-Haldane hypothesis}.

Wald G

He lived 1906 to 1997, studied life's origin, and studied found retina vitamin A [1934].

Miller S

He lived 1930 to ?. Methane, ammonia, and water heated by electric arcs make amino acids [1953 to 1954]. However, amino acids only polymerize if conditions are hot and dry.

Orgel L

Freezing can concentrate and align organic molecules to make nucleic acids, such as adenine [1970]. Mutations degrade good working genetic code to make it more varied {error catastrophe, Orgel}, and this process adds to genetic variability [1963].

Matthews C

Heteropolypeptides can come from hydrogen cyanide [1966]. Dry heating HCN makes heteropolyamidines. Water converts them to polypeptides.

Wachtershauser G

He studied life's origin [1988]. Hydrothermal-vent iron, nickel, and sulfur ions act as catalysts, templates, and energy sources to form biological molecules. Pyrite surfaces hold molecules.

Davies P

He studied relativity and life's origin.

Hazen R

Minerals have crevices in which molecules can hide from ultraviolet light and become concentrated [1996]. Clay and mineral surfaces can be chemical-reaction substrates, catalysts, and templates. Minerals, such as calcite, can have chirality and select for L or R organic molecules. Biological-molecule metal ions can act as catalysts or energy sources. Magnetite can catalyze ammonia formation from nitrogen and hydrogen. Iron, nickel, and sulfur ions are in hydrothermal vents.

Dyson F

He lived 1923 to ?.

4-Biology-History-Physiology

Jones John doctor

He studied opium effects.

Galvani L

He lived 1737 to 1798 and observed frog muscles twitch when touched by electrified wires {galvanic stimulation} [1780].

Beddoes T

He lived 1760 to 1808 and discovered analgesic effects of nitrous oxide [1798].

Spurzheim J

He lived 1776 to 1832 and studied memory storage and retrieval and physiological bases of normal brain function.

Magendie F

He lived 1783 to 1855, studied emetine and morphine drugs, and studied iodides and bromides in nutrition. He poisoned animals with Javanese arrow poison in various ways, described convulsions and asphyxia, sectioned spinal cord, and isolated strychnine [1818]. Spinal-nerve anterior and posterior roots have separate functions {Bell-Magendie law, Magendie}: dorsal root is sensory, and ventral root is motor [1822].

Beaumont W

He lived 1785 to 1853 and observed stomach functions [1822 to 1833].

Dutrochet H

He lived 1776 to 1847, studied osmosis [1824], studied plant respiration and light sensitivity [1824 to 1830], and worked on cell theory.

Muller J

He lived 1801 to 1858 and founded modern physiology. Sensation type depends on stimulated neurons, not on what stimulates them {doctrine of specific nerve energies, Muller}.

Matteucci C

He lived 1811 to 1868. Muscle cells have electric current [1842].

Wells Ho

He lived 1815 to 1848 and first used nitrous-oxide anesthetic [1844] when he extracted his tooth.

Du Bois-Reymond E

He lived 1818 to 1896. Nerve cells have resting potential [1845] that decreases with nerve impulse. Nerves conduct electricity. Nerve impulses transmit chemically [1877].

Berthold A

He lived 1803 to 1861 and studied hormones [1849] and transplantation.

Bernard C

He lived 1813 to 1878, studied pancreas [1849], studied liver and carbohydrates [1851], and noted curare's effects on nerve transmission to muscle [1853]. Anesthetics affect single cell organisms, such as green slime mold, amoebae, and paramecia [1875]. Internal environments {milieu interieur} can have constancies {homeostasis, Bernard}.

Gudden B

He lived 1824 to 1886. After axons are cut, neuron cell bodies often die and disappear {retrograde cell degeneration} [1870], providing method to study nerve pathways.

Ranvier L

He lived 1835 to 1922 and studied neuron axons and conduction [1878].

Gotch F

He lived 1853 to 1913 and studied nerve impulse, which has refractory period [1899].

Bidwell S

He lived 1848 to 1909. Alternating flashing lights can make afterimages {Bidwell's ghost}.

Bernstein J

He lived 1839 to 1917 and measured nerve-impulse conduction speed [1902]. Neural ion concentrations change slightly during nerve impulses and cause nerve potential differences and action potentials {membrane theory} [1902 to 1912]. Local electric current flows between axon resting region and impulse region and causes depolarization {local circuit hypothesis}. This was idea of Ludimar Hermann.

Pavlov I

He lived 1849 to 1936 and studied neurosis, peripheral nerves, digestion physiology, classical conditioning, and reflexes.

Contradictory stimuli can disturb balance between nervous-system excitatory and inhibitory processes, and personality affects whether neurosis develops.

Vagus nerve controls blood pressure, and four nerves control and vary heartbeat rhythm and intensity. Depending on saliva and food, tasting food {sham feeding} can release gastric juice, which has enzymes {enterokinase}.

Dogs associate neutral stimulus with reflex. Conditional reflex forms more easily if unconditional stimulus, such as food, follows conditional stimulus, such as bell, than if they are simultaneous or if conditional stimulus follows unconditional stimulus. Conditional reflex forms more easily if conditional stimulus is nearer in time to unconditional stimulus. Conditional stimulus that starts just before unconditional stimulus is as effective as conditional stimulus that started long before unconditional stimulus and lasted until just before. More intense conditional and unconditional stimuli cause greater conditioned responses. Training conditional stimulus allows testing similar conditional stimuli to investigate animal sense discriminations. External inhibition, internal inhibition, new environments, and new stimuli affect conditioning. If conditional and unconditional stimuli no longer pair, conditioned reflex gradually decreases. Maintaining conditioned reflex requires regular reinforcement. Conditioned reflex is similar to other reflexes. Conditional reflex formation is adaptation whereby animal can survive better in changing environment.

Blackman F

He lived 1866 to 1947 and studied light and dark photosynthesis [1905].

Cushing H

He lived 1869 to 1939, stimulated brains and elicited sensation without movement [1908], and described Cushing's syndrome [1912].

Lucas K

He lived 1879 to 1916 and studied nerve impulse, with Francis Gotch. Nerve impulse is all-or-nothing, with refractory period afterward [1909].

Henning H

He lived 1885 to 1946. He identified four bitter, salty, sour, and sweet primary tastes [1924], which he put at tetrahedron corners. He identified six primary smells [1916], which he put at prism corners.

Evans Long

Evans lived 1882 to 1971. Long lived 1879 to 1953. They isolated human growth hormone [1921].

Loewi O

He lived 1873 to 1961, proved that neurotransmitters cross junction between nerve cells, using vagus nerve to heart, and so proved that synapses were chemical not electrical [1921], and studied acetylcholine chemical synapse.

Adrian E

He lived 1889 to 1977 and recorded afferent-nerve impulses, with Lucas' capillary electrometer [1925]. Neurons use impulse-frequency modulation.

Lashley K

He lived 1890 to 1958 and studied cerebral-cortex lesion effects on intelligence, rat maze learning [1920 to 1930], and mass-action law [Lashley, 1956].

Flexner L

He lived 1902 to 1996. Long-term memory needs protein synthesis.

Dale H

He lived 1875 to 1968 and studied chemical synapses [1936].

Hodgkin A

Hodgkin lived 1914 to 1998. Huxley lived 1917 to ?. They used squid giant axons to prove that ions flow across membrane rather than down axon {local circuit hypothesis, Hodgkin}, by locally increasing and decreasing extracellular-fluid conductivity [1937]. Sodium ions have ion channels, and potassium ions have separate ion channels. During action potentials, membranes are first more permeable to sodium ions, flowing in, and then potassium ions, flowing out, so potential becomes negative {Hodgkin-Huxley theory} [1952].

Bernstein N

He lived 1896 to 1966 and developed sensation fields {afferent field, Bernstein}. He studied feedback and feedforward mechanisms. He studied human coordination and movement physiology by photographing lights fastened to arms and legs. Human movements have patterns and structures, and people maintain basic patterns no matter which organ or limb they use [Bernstein, 1947].

Katz B

He lived 1911 to 2003. Action potentials open calcium-ion channels, and calcium inflow leads to release of 5000-transmitter-molecule packets from synaptic vesicles into synapse.

Cade J

He lived 1912 to 1980 and used lithium carbonate to treat mania [1949].

Delgado J

He lived 1915 to ?. Amygdala stimulation by electrodes {stimoceiver} can trigger aggressive behavior [1955].

Kuffler S

He lived 1913 to 1980. Cat-retina ON-center and OFF-center ganglion cells respond to illumination changes [1953].

Vigneaud V

He lived 1901 to 1978 and discovered vasopressin [1953].

Couteaux R

He lived 1909 to 1999. Synaptic vesicles release transmitter packets only at active synapse zones {active zone}, where calcium ion channels are [1961].

Agranoff B

He lived 1926 to ?. Long-term memory needs protein synthesis.

Benzer S

He lived 1921 to ?, studied fruit flies, and mutated single genes to affect courtship rituals, vision, circadian rhythms, memory, and learning. He found proteins used in non-declarative memory.

Rowland Blumenthal V

.

Kandel E

He studied learning and memory in marine snails.

Albus J

He developed Cerebellar Model Articulation Controller [1975].

DeValois R

He showed that visual cortical neurons respond to frequency rather than edges or lines {direct spatial information} [1975]. They detect fundamental frequency and higher frequencies, together with orientation. He used gratings, checkerboards, and plaid patterns. Results matched results expected from analysis by Fourier transforms.

Arbib M

He lived 1940 to ?.

McEwen B

.

Gray E

.

Friedmann I

.

Palm G

.

Huber Thorson

.

Varela F

He lived 1946 to 2001 and studied neurophenomenology. Living cells rebuild themselves {autopoiesis, Varela} [1988], with Maturana.

Hobson J

He studied sleep and developed AIM model [Hobson, 2002].

Nicoll R

Special neuron stimulation can cause excitation over hours, involving protein-kinase phosphorylation after calcium-ion influx [1991].

Morris Ri

Only active synapses can take up protein to permanently alter synapse [1997], with Uwe Frey.

Flohr H

Inhibition or blocking of NMDA receptor complexes, as done by ketamine and nitrous oxide, causes unconsciousness [2000]. Consciousness is a high-level representation that brain has representations, using NMDA-receptor-linked cell assemblies firing synchronously [Flohr, 2000]. However, NMDA receptors are just as involved in non-conscious processes [Hardcastle, 2000]. Many anesthetics, such as etomidate, act on other sites [Franks and Lieb, 2000].

4-Biology-History-Sensation

Weber E

He lived 1795 to 1878, studied psychophysics, invented theory of signs {Lokalzeichentheorie}, measured skin sensitivity to separated stimuli [1826], studied inhibition by vagus nerve [1845], and developed law of sensation [1834], with Fechner. People can distinguish between two similar sensations {just-noticeable difference}. For each sense, ratio of just-noticeable-difference to intensity is approximately constant for all intensities. Subjective sensation increases as logarithm of physical-stimulus magnitude. Just-noticeable difference increases in direct proportion to stimulus intensity. If I is sensation intensity, intensity change divided by intensity equals constant {Weber-Fechner law} {Weber's law}: (I2 - I1) / I1 = Weber's constant. Weber's constant {Weber fraction} represents smallest stimulus intensity difference that people can perceive. If intensity is higher, differences must be larger for people to perceive them. Weber's constant is typically greater than one to three percent, differs for different senses, and tends to increase with age.

Brillat-Savarin J

He lived 1755 to 1826.

Kuhne W

He lived 1837 to 1900 and found rhodopsin retinal pigment {visual purple} in rod photoreceptors for twilight vision [1877].

Hering E

He lived 1834 to 1918. Lung receptors signal distension, stop inspiration {Hering-Breuer reflex}, and partly control respiration.

He explained brightness perception, color vision, afterimages, and complementary colors by starting from neutral point and moving in anabolic or catabolic direction {opponent color theory, Hering}. Yellow does not subjectively appear to mix green and red and is stable over intensity changes, so yellow is a primary-color complement. Eye-movement, color-detection, and brightness-detection mechanisms are inborn. People see unique blue, unique green, and unique yellow, because they affect all three cones and, at that wavelength, people perceive no other color mixed in. People do not see unique red, because only two cones affect red.

Brain substance can contain memories, and memory is a material process, because memory survives unconsciousness and sleep.

Fabre J

He lived 1823 to 1915 and studied insect behavior and sense capacities.

Frey Max

He lived 1852 to 1932 and studied pain and touch sensations.

von Frisch K

He lived 1886 to 1983. Fish can have color vision and can hear. Special honeybees {scout honeybee} convey information about food-source direction and distance by performing symbolic dances after they return to hive floor. Bee determines direction in reference to Sun or to sky light-polarization angle, detectable by bee compound eye. Dances have a symmetry line, which indicates food-source direction. Dance kinds and speeds indicate food-source distance: slow and round for near and fast, and waggly for far.

Maturana H

He lived 1928 to ?. Living cells rebuild themselves {autopoiesis, Maturana}.

Wiesel T

He lived 1924 to ? and studied visual-cortex organization, with David Hubel. Not using eye during critical or sensitive period to detect stimulus feature makes visual cortex unable to detect stimulus feature {sensory deprivation, Wiesel}.

Hubel D

He lived 1926 to ? and studied visual-cortex organization, with Torsten Wiesel. Not using eye during critical or sensitive period to detect stimulus features makes visual cortex unable to detect stimulus features.

Brain detects color in round vertical columns, located 0.5 mm apart in regular arrays between primary-visual-cortex orientation columns, using double-opponent neurons, with both ON-center and OFF-center circular fields, to compare colors. He found blobs by staining primary visual cortex with cytochrome oxidase (CO), with Margaret Livingstone. Interblob regions detect orientation.

Matthews G

.

Koch C

He lived 1956 to ?. Neural activity differs in dreaming, awake, or brain-damaged {activity principle, Koch}. Different animal types can have different neural-activity patterns. Perhaps, some neuron set has same ion channels, shape, receptors, axons, or biochemistry {neuronal correlates of consciousness, Koch}.

4-Biology-History-Surgery

Osler W

He lived 1849 to 1919.

4-Biology-History-Zoology

Lamarck J

He lived 1744 to 1829 and studied invertebrate paleontology and invertebrate classification. Environment forces animals to acquire new characteristics through learning. What individual experience learns, offspring can inherit {Lamarckianism, Lamarck}. However, Lamarckianism is only true for minor specialized cellular transmittance.

Darwin E

He lived 1731 to 1802.

Wollaston T

He lived 1822 to 1878.

Jennings H

He lived 1868 to 1947 and studied invertebrates.

Beebe C

He lived 1877 to 1962 and deep-sea dived.

Peterson Ro

He lived 1908 to 1996 and studied birds.

Bates M

He lived 1906 to 1974 and studied mosquitoes.

Gould J

.

Fenton B

.

Related Topics in Table of Contents

4-Biology

Drawings

Drawings

Contents and Indexes of Topics, Names, and Works

Outline of Knowledge Database Home Page

Contents

Glossary

Topic Index

Name Index

Works Index

Searching

Search Form

Database Information, Disclaimer, Privacy Statement, and Rights

Description of Outline of Knowledge Database

Notation

Disclaimer

Copyright Not Claimed

Privacy Statement

References and Bibliography

Consciousness Bibliography

Technical Information

Date Modified: 2022.0225